Pathobiology for Investigators, Students, and Academicians
Young Investigators Virtual Meeting
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Click on the links below to go directly to that day's program information
Tuesday | Wednesday | Thursday
Tuesday, October 5, 2021
SESSION 1 - Cancer Pathobiology and Neuropathology
Session Co-Chairs: Alexander T. Sougiannis, PhD • Michelle Alves, PhD
12:30 PM - 3:30 PM (EST)
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12:30 PM -
1:15 PM (EST)
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Isaiah J. Fidler Memorial Keynote Lecture
“The Metastatic Cell is a Decathlon Champion”
Diane R. Bielenberg, PhD • Boston Children's Hospital/Harvard Medical School
Dr. Diane Renee Bielenberg received a BS in Chemistry and Biology from the University of Northern Iowa and a PhD in Cancer Biology from the University of Texas Health Science Center and MD Anderson Cancer Center. Dr. Bielenberg performed her post-doctoral studies as an American Cancer Society Fellow at Harvard Medical School and Children's Hospital. She joined the Vascular Biology Program as an Associate Professor in 2005. Dr. Bielenberg has received several grant awards including the Howard Temin Award from the NCI, the Dr. Patricia Wexler Award from the Skin Cancer Foundation, and the Patterson Trust Award. In 2008, Dr. Bielenberg received the Harvard Medical School Young Mentor Award.
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Young Investigator Short Talks
- 1:15 PM - 1:30 PM (EST)
CAN1 - DCLK1 Promotes Cisplatin Resistance in Ovarian Cancer
Samrita Dogra1,2, Katherine Moxley2,3, and Bethany N. Hannafon1,2
1Department of Obstetrics and Gynecology, 2Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 3Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI
- 1:30 PM - 1:45 PM (EST)
CAN2 - Targeting the DNA Damage Response Pathway by Combination of ATR and PARP Inhibition Imparts Synthetic Lethality to Cervical Cancer Cells
Marlee Hill1, Sugantha Priya Elayapillai2,3, Bethany N. Hannafon2,3, and Katherine Moxley2,4
1College of Medicine, University of Oklahoma, Oklahoma City, OK, 2Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 3Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI
- 1:45 PM - 2:00 PM (EST)
CAN3 - Collagen Hydroxyproline Analysis of Colon Cancer Polyps in Patients Within the Appalachian Mountain Region
Alexander T. Sougiannis1, Gavin T. Cauley1, and Peggi M. Angel2
1Medical University of South Carolina, College of Medicine, Charleston, SC, 2Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, SC
- 2:00 PM - 2:15 PM (EST)
CAN4 - CECR2 Drives Breast Cancer Metastasis by Suppressing Macrophage Inflammatory Responses
Meiling Zhang and Qin Yan
Department of Pathology, Yale School of Medicine, New Haven, CT
- 2:15 PM - 2:30 PM (EST)
NEURO1 - PECAM-1 Blockade Reduces Neutrophil Infiltration into the Subcortex Post-Stroke
Erika Arias, Neil Avadhoot Nadkarni, Raymond S. Fang, Maureen Haynes, Ayush Batra, William A. Muller, and David P. Sullivan
Department of Pathology, Northwestern University, Chicago, IL
- 2:30 PM - 2:45 PM (EST)
NEURO2 - AAV-mediated Gene Replacement Therapy is Beneficial in Unverricht-Lundborg Disease Mouse Model
Emrah Gumusgoz, Sahba Kasiri, Jun Wu, Matthew Dear, Xin Chen, and Berge Minassian
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX
- 2:45 PM - 3:00 PM (EST)
NEURO3 - Neuronal Death and Inflammation in Brain of SARS-CoV-2 Infected Non-Human Primates Meredith G. Mayer2, Ibolya Rutkai1, Linh M. Hellmers2, Bo Ning3, Zhen Huang3, Christopher J. Monjure2, Carol Coyne2, Rachel Silvestri2, Nadia Golden2, Krystle Hensley2, Kristin Chandler2, Gabrielle Lehmicke2, Gregory J. Bix1, Nicholas J. Maness2, Kasi Russell-Lodrigue2, Tony Y. Hu3, Chad J. Roy2, Robert V. Blair2, Rudolf Bohm2, Lara A. Doyle-Meyers2, Jay Rappaport2, and Tracy Fischer2
1Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA’ 2Tulane National Primate Research Center, Covington, LA, 3Center for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, LA
- 3:00 PM - 3:15 PM (EST)
NEURO4 - Interactions Between Autophagy, Herpesvirus, and Neurodegeneration in Alzheimer’s Disease
Amir Nafchi1, Mona Esmaeili1, Pouya Raeisinafchi2, Orrin Myers4, and Elaine Bearer3
1Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, 2Department of Psychology, Neuroscience & Behavior, McMaster University, Hamilton, ON, Canada, 3Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, 4Department of Family and Community Medicine, University of New Mexico School of Medicine, Albuquerque, NM
- 3:15 PM - 3:30 PM (EST)
NEURO5 - Early Life Adversity Potentiates Adult Response to Acute Threat: A Brain-Wide Neuroimaging and Behavior Study
Taylor W. Uselman1, Russell E. Jacobs2, Elaine L. Bearer1,3
1Department of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, 2Zilkha Neurogenetic Institute, USC Keck School of Medicine, Los Angeles, CA, 3Biology and Biological Engineering, Caltech, Pasadena, CA
3:30 PM -
4:00 PM (EST) |
COFFEE BREAK |
SESSION 2 - Pathobiology of Infectious Disease
Session Co-Chairs: Kristen Engevik, PhD • Francisco J. Carrillo-Salinas, PhD
4:00 PM - 6:00 PM (EST)
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4:00 PM -
4:45 PM (EST)
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Emanuel Rubin Memorial Keynote Lecture
“Understanding HIV Infection in the Female Genital Tract”
Marta Rodriguez-Garcia, MD, PhD • Tufts University School of Medicine
Dr. Marta Rodriguez-Garcia is an Assistant Professor of Immunology at Tufts University School of Medicine. Her NIH-funded laboratory focuses on understanding mucosal acquisition of HIV in women and how innate immune protection changes as women age. Her studies integrate the many aspects that influence mucosal protection in the genital tract, including age, hormonal fluctuations, tissue environment and pathogen/microbiome exposure, which make the study of this mucosal surface unique and challenging. Dr. Rodriguez-Garcia will present current knowledge and new findings on how HIV infection is established in the female genital mucosa.
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Young Investigator Short Talks
- 4:45 PM - 5:00 PM (EST)
IND1 - Sofia SARS Antigen FIA and Reverse-Transcriptase Polymerase Chain Reaction: Comparing Diagnostic Methods
Blaire Anderson1, Anna Bouck1, Michael Lambert2, Dorothy Martin1,2, Heather Steinmetz1, Samantha Allen1, Joel Lefferts1, and Bing Ren1,2
1Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, 2Department of Pathology and Laboratory Medicine, Springfield Hospital, Springfield, VT
- 5:00 PM - 5:15 PM (EST)
IND2 - Estradiol Levels Influence Neutrophil Responses Against HIV in Women
Anna Borchers1, Laura Moreno de Lara1,2, Ragav S Parthasarathy1,3, Christina Ochsenbauer4, Alexander Panda5,6, Francisco J. Carrillo-Salinas1, and Marta Rodriguez-Garcia1,3
1Department of Immunology, Tufts University School of Medicine, Boston MA, 2Immunology Unit, Biomedical Research Centre, University of Granada, Granada, Spain, 3Immunology Program, Tufts Graduate School of Biomedical Sciences, Boston, MA, 4Department of Medicine and UAB Center for AIDS Research, University of Alabama, Birmingham, AL, 5Tufts Medical Center/Division of Pulmonary and Critical Care, Boston, MA, 6Tufts Clinical and Translational Science Institute, Boston, MA
- 5:15 PM - 5:30 PM (EST)
IND3 - SCFAs Impact Neutrophil Response to HIV Infection
Francisco J. Carrillo-Salinas1, Ragav S. Parthasarathy1,2, Laura Moreno de Lara1,3, Anna Borchers1, Christina Ochsenbauer4, Alexander Panda5,6, and Marta Rodriguez-Garcia1,2
1Department of Immunology, Tufts University School of Medicine, Boston, MA, 2Immunology Program, Tufts Graduate School of Biomedical Sciences, Boston, MA, 3Immunology Unit, Biomedical Research Centre, University of Granada, Granada, Spain, 4Department of Medicine and UAB Center for AIDS Research, University of Alabama, Birmingham, AL, 5Tufts Medical Center/Division of Pulmonary and Critical Care, Boston, MA, 6Tufts Clinical and Translational Science Institute, Boston, MA
- 5:30 PM - 5:45 PM (EST)
IND4 - Elucidating the Role of Host Purinergic Signaling During Rotavirus Infection
Kristen A. Engevik1, John T. Gebert1, Jacob L. Perry1, Francesca J. Scribano1, Takahiro Kawagishi2, Harry Greenberg2, and Joseph M. Hyser1
1Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston TX, 2Department of Medicine, Gastroenterology & Hepatology Stanford University, Stanford, CA
- 5:45 PM - 6:00 PM (EST)
IND5 - Klebsiella Pneumoniae in the Colonic Mucus Layer Influences Clostridioides Difficile Pathogenesis
Taylor Ticer and Melinda A. Engevik
Department of Regenerative Medicine, Medical University of South Carolina, Charleston, SC
Wednesday, October 6, 2021
SESSION 3 - Vascular Pathobiology
Session Co-Chairs: Tendai Hunyenyiwa, MS • Ramon Bossardi Ramos, PhD
12:30 PM - 3:00 PM (EST)
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12:30 PM -
1:15 PM (EST)
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Jay M. McDonald Memorial Keynote Lecture
“A Role for the Glycocalyx in Angiogenesis”
Patricia A. D'Amore, PhD, MBA • Schepens Eye Research Institute/Harvard Medical School
Dr. Patricia A. D'Amore grew up in Everett, Massachusetts and received a PhD in biology from Boston University in 1977. She conducted post-doctoral research in the Department of Ophthalmology and the Department of Physiological Chemistry at Johns Hopkins University School of Medicine, where she was appointed Instructor in 1979 and Assistant Professor in 1980.
Dr. D'Amore returned to Boston in 1981 to join Dr. Judah Folkman in the Program in Vascular Biology at Boston Children's Hospital (then the Surgical Research Laboratories), where she has since served as a Research Associate in the Department of Surgery. Additionally, she obtained a MBA from Northwestern University in 1987. Dr. D'Amore was appointed Associate Professor of Pathology at Harvard Medical School in 1989. In 1998, she became Professor of Ophthalmology at Harvard Medical School, and also joined Schepens Eye Research Institute (an affiliate of Harvard Medical School) as a Senior Scientist. In 2012, she was appointed the Charles L. Schepens Professor of Ophthalmology at Harvard Medical School and Director of research at the Schepens Eye Research Institute of Mass Eye and Ear. In 2014, she was appointed Professor of Pathology at Harvard Medical School, she was also appointed Director of the Howe Laboratory and the Associate Chief for Ophthalmology Basic and Translational Research in the Department of Ophthalmology.
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Young Investigator Short Talks
- 1:15 PM - 1:30 PM (EST)
VASC1 - Neuropilin-1 Regulates Vascular Smooth Muscle Cell Contractility and Blood Pressure
Dakshnapriya Balasubbramanian1,2, George Lambrinos2,3, Vivian Cristofaro2,4, Alexander Bigger-Allen2,3, Beibei Wang1,2, Yao Gao1,2, Hong Chen1,2, Rosalyn M. Adam2,3, Maryrose P. Sullivan2,4, and Diane R. Bielenberg1,2
1Vascular Biology Program, Boston Children’s Hospital, Boston, MA, 2Department of Surgery, Harvard Medical School, Boston, MA, 3Department of Urology Research, Boston Children’s Hospital, Boston, MA, 4Division of Urology, Veterans Affairs Boston Healthcare System, Boston, MA
- 1:30 PM - 1:45 PM (EST)
VASC2 - Loss of the Smooth-muscle-cell-Angiotensin II-sensitive (SAS) lncRNA Triggers VSMC Hypertrophy and Cell Cycle Arrest: Application to Hypertension and Aortic Stiffness
Cristina Espinosa-Diez, Mingjun Liu, Mingyuan Du, Sidney Mahan, and Delphine Gomez
Department of Medicine, University of Pittsburgh, Pittsburgh, PA
- 1:45 PM - 2:00 PM (EST)
VASC3 - Specific Role of Endomucin in Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Internalization and Function
Zhengping Hu1,2, Issahy Cano1,2, Magali Saint-Geniez1,2, Eric Ng1,2, and Patricia A. D’Amore1,2,3
1Pathology, Harvard Medical School, Boston, MA3Departments of Ophthalmology and 2Schepens Eye Research Institute of Massachusetts Eye and Ear, 2Departments of Ophthalmology and 3Pathology, Harvard Medical School, Boston, MA
- 2:00 PM - 2:15 PM (EST)
VASC4 - Obesity Inhibits Angiogenesis Through TWIST1-SLIT2 Signaling
Tendai Hunyenyiwa, Kathryn Hendee, Kienna Matus, Priscilla Kyi, Tadanori Mammoto, and Akiko Mammoto
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
- 2:15 PM - 2:30 PM (EST)
VASC5 - COVID Coronary Vascular Thrombosis: Correlation with Neutrophil But Not Endothelial Activation
Justin E. Johnson1, Dan Jane-wit1,2, Declan McGuone3, Mina L. Xu3, Richard N. Mitchell4, Peter Libby5, Jordan S. Pober1
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 2Department of Cardiology, West Haven VA Medical Center, West Haven, CT, 3Department of Pathology, Yale University School of Medicine, New Haven, CT, 4Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 5Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
- 2:30 PM - 2:45 PM (EST)
VASC6 - H3K4 Di-methylation Governs Smooth Muscle Lineage Identity and Promotes Vascular Homeostasis by Restraining Plasticity
Mingjun Liu 1,2, Cristina Espinosa-Diez 1, Sidney Mahan1, Mingyuan Du1,3, Anh T. Nguyen4, Scott Hahn1, Raja Chakraborty5,6, Adam C. Straub1,7,8, Kathleen A. Martin5,6, Gary K. Owens4,9, and Delphine Gomez1,2
1Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 2Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 3Department of Vascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, China, 4Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, 5Internal Medicine, Cardiovascular Medicine Section, Yale Cardiovascular Research Center, Yale University, New Haven, CT, 6Department of Pharmacology, Yale University, New Haven, CT, 7 Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 8Center for Microvascular Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, 9Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA
- 2:45 PM - 3:00 PM (EST)
VASC7 - SNAP29 Restricts Cardiac Arrhythmias by Insulating a Subset of Desmosomal Proteins and Connexin43 from Autophagic Degradation
Jie Wang, Jason Pellman, Robert Lyon, Yan Liang, Valeria Mezzano, Jing Zhang, Vishal Nigam, Yusu Gu, Nancy Dalton, Kirk L. Peterson, and Farah Sheikh
Department of Medicine, University of California - San Diego, San Diego, CA
3:00 PM -
3:30 PM (EST) |
COFFEE BREAK |
SESSION 4 - Inflammation and Immunopathology
Session Co-Chairs: Nakisha Rutledge, BS • Erik Butcher, PhD
3:30PM - 6:15 PM (EST)
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3:30 PM -
4:15 PM (EST)
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Janardan K. Reddy Memorial Keynote Lecture
“How Inflammation Begets Pathology”
William A. Muller, MD, PhD • Northwestern University
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Young Investigator Short Talks
- 4:15 PM - 4:30 PM (EST)
INFL1 - Adipose Tissue Role in Neonatal Sepsis
Michele J. Alves, Juliet Torres, Silvio Fernandes de Araujo Junior, Paollo Fadda, Jennifer Mele, Catherine Czeisler, and Jose Otero
Department of Pathology, The Ohio State University, College of Medicine, Columbus, OH
- 4:30 PM - 4:45 PM (EST)
INFL2 - Differentially Methylated Positions After IL-6 in the Endothelium
Ramon Bossardi Ramos, Nina Martino, and Alejandro Adam
Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY
- 4:45 PM - 5:00 PM (EST)
INFL3 - Identification and Characterization of a First Series of Small Molecule Inhibitors of Feline Islet Amyloid Polypeptide Aggregation
Kelsey E. Duggan1, Kendra N. Nylen2, Nurhanis B.M. Isa2, Malikah O’Dell2, and Jessica S. Fortin1,3
1College of Veterinary Medicine, Michigan State University, East Lansing, MI, 2Department of Chemistry, College of Natural Science, Michigan State University, East Lansing, MI, 3Current Address - Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN
- 5:00 PM - 5:15 PM (EST)
INFL4 - Identifying the Targets of Perforin Mediated Killing
Vineet Garlapally, Vandana Chaturvedi, and Michael Jordan
Department of Pathobiology and Molecular Medicine, University of Cincinnati, Cincinnati Children’s Hospital, Cincinnati, OH
- 5:15 PM - 5:30 PM (EST)
INFL5 - Cationic Antimicrobial Peptide, E35, Reduces LPS-induced Inflammation in Mice
Joud Mulla1, Sultan Abdelhamid1, Zachary Secunda1, Bashar Al Matour1, Nijmeh Alsaadi1, Berthony Deslouches2, and Melanie J. Scott1
1Department of Surgery, University of Pittsburgh, Pittsburgh, PA, 2Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA
- 5:30 PM - 5:45 PM (EST)
INFL6 - Perivascular Macrophages Prime Vascular Endothelial Cells to Promote Neutrophil Adhesion and Transendothelial Migration
Xingsheng Ren, Jessica M. Urbanczyk, and Ronen Sumagin
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL
- 5:45 PM - 6:00 PM (EST)
INFL7 - Human L2 Regulates Leukocyte Transmigration at a Unique Step between those Regulated by PECAM and CD99
Nakisha S. Rutledge, David P. Sullivan, Faith Ogungbe, and William A. Muller
Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL
- 6:00 PM - 6:15 PM (EST)
INFL8 - Interplay Between TNFα-induced Inflammation and Metabolic Dysfunction in Retinal Pigment Epithelial Cells
Daisy Y. Shu, Erik R. Butcher, Emmanuella Nnuji-John, Scott Frank, Rishi Shah, Siwei Cai, Deviprasad Gollapalli, and Magali Saint-Geniez
Schepens Eye Research Institute of Mass Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA
Thursday, October 7, 2021
SESSION 5 - Epithelial and Mucosal Pathobiology
Session Co-Chairs: Daisy Shu, PhD • Anny-Claude Luissint, PhD
12:30 PM - 3:00 PM (EST)
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12:30 PM -
1:15 PM (EST)
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Marilyn G. Farquhar Memorial Keynote Lecture
“Plasticity of the Mucosal Barrier: Insights into Regulation of Epithelial Homeostasis and Repair”
Asma Nusrat, MD • University of Michigan
After finishing residency training in Anatomic Pathology at the Brigham and Women’s Hospital (BWH)/Harvard Medical School, Dr. Asma Nursat completed a fellowship in Gastrointestinal and Hepatobiliary pathology, as well as a research fellowship in epithelial pathobiology at the same institution. While at BWH, she began investigating fundamental mechanisms of epithelial barrier regulation and wound repair. She remained at BWH as a faculty from 1992-1997, after which she was recruited to Emory University where she rose to the rank of full Professor. After receiving a Career Development Award and an RO1, Asma has been continuously funded by multiple grants from the NIH and private foundations. In 2015 she was recruited to the University of Michigan Medical School as the Alfred Scott Warthin Professor and Director of Experimental Pathology.
Asma is also a practicing Gastrointestinal and Liver Pathologist and has contributed to mentoring and teaching graduate and medical students, residents, postdoctoral fellows and junior faculty. She is an Associate Editor for Molecular Biology of the Cell and Gastroenterology.
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Young Investigator Short Talks
- 1:15 PM - 1:30 PM (EST)
MUC1 - Giardia Duodenalis Alters Biochemical Properties of Intestinal Mucus During Infection
Elena Fekete, Thibault Allain, and Andre G. Buret
Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
- 1:30 PM - 1:45 PM (EST)
MUC2 - Characterizing the Mucin-degrading Capacity of the Human Gut Microbiota
Janiece Glover, Taylor Ticer, and Melinda A. Engevik
Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC
- 1:45 PM - 2:00 PM (EST)
MUC3 - Annickia Polycarpa Extract Attenuates DSS-Induced Colitis by Balancing Neutrophil Recruitment
Nathaniel L. Lartey1, Hilda Vargas-Robles1, Idaira M. Guerrero-Fonseca1, Emmanuel K. Kumatia2, Augustine Ocloo3, and Michael Schnoor1
1Department of Molecular Biomedicine, CINVESTAV-IPN, Mexico-City, Mexico, 2Department of Phytochemistry, Centre for Plant Medicine Research. Akuapem-Mampong, Ghana, 3Department of Biochemistry, Cell, and Molecular Biology, University of Ghana, Legon-Ghana
- 2:00 PM - 2:15 PM (EST)
MUC4 - Giardia Muris Infection Leads to Tuft Cell Hyperplasia at Later Stages of Infection
Olivia Sosnowski, Thibault Allain, Elena Fekete, Derek M. McKay, and Andre G. Buret
Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
- 2:15 PM - 2:30 PM (EST)
MUC5 - Transcorneal Electric Stimulation Therapy Induce Dry Eye by [Ca2+]i Depletion of Goblet Cells and Reduce Mucin Production
Menglu Yang1, Anton Lennikov1, Kinsang Cho1, Karen Chang1, Tor Paaske Utheim2, Darlene Dartt1, and Dong Feng Chen1
1Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, 2Faculty of Medicine, University of Oslo, Oslo, Norway
2:30 PM -
3:00 PM (EST) |
COFFEE BREAK |
SESSION 6 - Liver Pathobiology
Session Co-Chairs: Vik Meadows, MS • Chhavi Goel, PhD
3:00 PM - 5:45 PM (EST)
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3:00 PM -
3:45 PM (EST)
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Emanuel Rubin Memorial Keynote Lecture
“The Many Tiers of Liver Repair: Prometheus Needed Them All”
Satdarshan P. Monga, MD • University of Pennsylvania
Dr. Satdarshan P. Monga is the Chair for Experimental Pathology, Vice Chair and Chief of Division of Experimental Pathology, Professor of Pathology (Division of Experimental Pathology), Professor of Medicine (Division of Gastroenterology, Hepatology & Nutrition), Assistant Dean for Medical Scientist Training Program, Director of Cellular Approaches to Tissue Engineering & Regeneration (CATER) Program, Associate Director of the University of Pittsburgh Drug Discovery Institute (UPDDI), and Director of the Pittsburgh Liver Research Center.
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Young Investigator Short Talks
- 3:45 PM - 4:00 PM (EST)
LIVER1 - TLR4 Deficiency Alters Platelet-Derived Exosome Release and Increases Mortality in a Model of Liver Regeneration
Nijmeh Alsaadi1, Hamza Yazdani1, Matthew D. Neal1, and Roberto Ivan Mota Alvidrez1,2,3
1Department of Surgery, 2McGowan Institute for Regenerative Medicine, 3Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
- 4:00 PM - 4:15 PM (EST)
LIVER2 - β-catenin Conditional Knockout Elicits Protection Against Lithocholic Acid-induced Cholestatic Injury in a Murine Model
Chhavi Goel1, Rong Zhang1, Pamela Cornuet1, Xiaochao Ma2, and Kari Nejak-Bowen1,3
1Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 2Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, 3Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA
- 4:15 PM - 4:30 PM (EST)
LIVER3 - Mitigation of High-Fat Diet-Induced Liver Injury in MS-NASH Mice: Modifications in Proteomic Signature
Isabelle Harber, Dania Zeidan, Shannon McClintock, and Muhammad Nadeem Aslam
Department of Pathology, University of Michigan, Ann Arbor, MI
- 4:30 PM - 4:45 PM (EST)
LIVER4 - PDGF Increases Hepatocyte-HMGB1 Synergistically with Stimulation of Heparan Sulfate in vitro and Alters Hepatocyte Exosome Release In TLR4 Deficient Mice
Zeyu Liu1, Nijmeh Alsaadi1, Hamza Yazdani1, Matthew D. Neal1, and Roberto Ivan Mota Alvidrez1,2,3
1Department of Surgery, 2McGowan Institute for Regenerative Medicine, 3Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA
- 4:45 PM - 5:00 PM (EST)
LIVER5 - Hepatic Autophagy Deficiency Leads to Exosome Overproduction and Pro-Inflammatory Response
Gang Liu, Michelle Ma, and Xiao-Ming Yin
Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA
- 5:00 PM - 5:15 PM (EST)
LIVER6 - Histamine increases Hepatic and Intestinal Mast Cell Activation and Regulates Bile Acid Signaling During PSC
Vik Meadows1, Debjyoti Kundu1, Vincent Zhou2, Lindsey Kennedy2, and Heather Francis2
1Department of Biochemistry and Molecular Biology, 2Department of Medicine, Indiana University School of Medicine, Indianapolis, IN
- 5:15 PM - 5:30 PM (EST)
LIVER7 - Durable Persistence of the Fetal Hepatocyte Phenotype After Liver Cell Transplantation
Anders W. Ohman and Jennifer A. Sanders
Department of Pathology and Laboratory Medicine, Brown University, Division of Pediatric Endocrinology, Rhode Island Hospital, Providence RI
- 5:30 PM - 5:45 PM (EST)
LIVER8 - Transcriptional Correlation Analysis of Livers Undergoing Normothermic Machine Perfusion Links Gene Expression Patterns with Graft Functional Metrics
John Santiago1, Siavash Raigani2, Anders Ohman1, Korkut Uygun3, Heidi Yeh3, and Jennifer A. Sanders1
1Department of Pathology and Laboratory Medicine, Brown University, 2Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3Transplant Surgery, Massachusetts General Hospital, Boston, MA